GLP-1 Active Form ELISA

GLP-1 Active Form ELISA

Brand: IBL
Product Code: JP27784
Availability:
In Stock
Description

GLP-1 Active Form ELISA Kit - Research Use Only

Incretins are a group of gastrointestinal hormones that cause an increase in the amount of insulin released from the beta cells of the islets of Langerhans after eating. They also inhibit glucagon release from the alpha cells of the islets of Langerhans. As a result, they slow the rate of absorption of nutrients into the blood stream by reducing gastric emptying and may directly reduce food intake.

The two main candidate molecules that fulfill criteria for an incretin are glucagon-like peptide-1 (GLP-1) and Gastric inhibitory peptide (or glucose-dependent insulinotropic polypeptide or GIP). The human proglucagon gene was cloned in 1983, and the human proglucagon sequence was subsequently deduced. After that, it was found that the specific sequence of GLP-1 has insulinotropic effect: GLP-1 (7-36) amide. Now, GLP-1 (7-36) amide and GLP-1 (7-37) are known as active forms of GLP-1. They are rapidly inactivated to GLP-1 (9-36) amide and GLP-1 (9-37) by DPP-IV within a few moments in blood. This ELISA kit can measure active forms of GLP-1 (GLP-1 (7-36) amide and GLP-1 (7-37)) specifically.

96 well ELISA microplate

Incubation time: 2 h 40 min

Range: 1.25 - 80 pmol/L

Sensitivity: 0.10 pmol/L

Diluted Sample size: 100 µl

Sample type: EDTA plasma with DPP-IV inhibitor to preserve GLP-1.

Substrate: TMB 450nm

Tags:
Tags: GLP-1, incretin

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